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Mitochondrial DNA mutations in the haematopoietic system

Leukemia volume 18, pages 169–170 (2004)Cite this article

TO THE EDITOR

The invited commentary by Gattermann,1 which accompanies our paper in this issue of Leukemia2 summarises what is currently known about the role of mitochondrial DNA (mtDNA) mutations in the haematopoietic system. In addition to his previous work on myelodysplastic syndromes (MDS),3 our recent studies2 show that somatic mtDNA mutations are present in some patients with leukaemia. What are the wider implications of this observation?

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References

  1. Gattermann N . Mitochondrial DNA mutations in the hematopoietic system. Leukemia 2003, advance online publication 13 November 2003; doi: 10.1038/sj.leu.2403209.

  2. He L, Luo L, Proctor SJ, Middleton PG, Blakely EL, Taylor RW et al. Somatic mitochondrial DNA mutations in adult-onset leukaemia. Leukemia 2003, advance online publication 2 October 2003; doi: 10.1038/sj.leu.2403146.

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Authors and Affiliations

  1. Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, Framlington Place, University of Newcastle upon Tyne, UK

    R W Taylor, L He & D M Turnbull

  2. Department of Academic Haematology, The Medical School, Framlington Place, University of Newcastle upon Tyne, UK

    S J Proctor & P G Middleton

Authors
  1. R W Taylor
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  2. L He
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  3. S J Proctor
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  4. P G Middleton
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  5. D M Turnbull
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Correspondence to R W Taylor.

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Taylor, R., He, L., Proctor, S. et al. Mitochondrial DNA mutations in the haematopoietic system. Leukemia 18, 169–170 (2004). https://doi.org/10.1038/sj.leu.2403208

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