Abstract
BCL10, a gene involved in apoptosis signalling, has recently been identified through the cloning of chromosomal breakpoints in extranodal (MALT-type) marginal zone lymphomas carrying the t(1;14)(p22;q32) translocation. BCL10 was also found mutated in these cases as well as in other types of lymphoid and solid tumors, suggesting that its inactivation may play an important pathogenetic role; however, this has been questioned by recent studies showing a lack of somatic mutations in human cancers. We report the mutation analysis of exons 1–3 of the BCL10 gene in DNAs from 228 cases of lymphoid malignancies (30 B cell chronic lymphocytic leukemias, 123 B and 45 T non-Hodgkin's lymphomas and 30 multiple myelomas). Somatic mutations were detected in four cases (2%): one small lymphocytic, one follicular and two diffuse large cell lymphomas. The mutations were all within exon 3 and have not been previously reported. Our data suggest that BCL10 mutations may play only a limited role in the pathogenesis of lymphoid neoplasms.
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Acknowledgements
This work was supported by grants from the Associazione Italiana Ricerca sul Cancro (AIRC) (to AN), Ministero Italiano della Sanità, and Swiss National Science Foundation (No. 32-45993.95) and Schweizerische Krebsliga/Krebsforschung Schweiz (No. AKT 623) (to EZ).
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Luminari, S., Intini, D., Baldini, L. et al. BCL10 gene mutations rarely occur in lymphoid malignancies. Leukemia 14, 905–908 (2000). https://doi.org/10.1038/sj.leu.2401747
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DOI: https://doi.org/10.1038/sj.leu.2401747
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