Abstract
For most autoimmune disorders, the pattern of inheritance is very complex. The major histocompatibility complex (MHC) gene complex has been implicated as the major genetic component in the predisposition to these diseases but other genes are likely to be involved. Based on function and experimental data, the gene encoding cytotoxic T lymphocyte-associated antigen 4 (CTLA4) has been suggested as a candidate gene for conferring susceptibility to autoimmunity. In this review, we critically evaluate the evidence for pathogenetical involvement of CTLA-4 in the different autoimmune diseases with focus on the possible role of genetic variation of the CTLA4 locus.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 6 digital issues and online access to articles
$119.00 per year
only $19.83 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
This work was in part supported by The Juvenile Diabetes Foundation International (JDFI No. 3-1999-21, OPK), The Danish Medical Research Council (No. 9802011 ZML) and the EU Biomed 2 (No. BMH4-97-2311 FP).
Rights and permissions
About this article
Cite this article
Kristiansen, O., Larsen, Z. & Pociot, F. CTLA-4 in autoimmune diseases – a general susceptibility gene to autoimmunity?. Genes Immun 1, 170–184 (2000). https://doi.org/10.1038/sj.gene.6363655
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.gene.6363655
Keywords
This article is cited by
-
Association between type 1 diabetes and systemic lupus erythematosus: a Mendelian randomization study
Clinical Rheumatology (2024)
-
Influence of cytotoxic T lymphocyte antigen 4 genetic variants on acute rejection in kidney transplant patients: precision medicine perspective
Journal of Diabetes & Metabolic Disorders (2022)
-
Genetic and molecular biology of systemic lupus erythematosus among Iranian patients: an overview
Autoimmunity Highlights (2021)
-
The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity
Cell Research (2020)
-
Message from the new Editors-in-Chief
Genes & Immunity (2019)