Abstract
The inhalation of medical aerosols is widely used for the treatment of lung disorders such as asthma, chronic obstructive pulmonary disease1, cystic fibrosis2, respiratory infection3 and, more recently, lung cancer4. Targeted aerosol delivery to the affected lung tissue may improve therapeutic efficiency and minimize unwanted side effects. Despite enormous progress in optimizing aerosol delivery to the lung, targeted aerosol delivery to specific lung regions other than the airways or the lung periphery has not been adequately achieved to date5,6. Here, we show theoretically by computer-aided simulation, and for the first time experimentally in mice, that targeted aerosol delivery to the lung can be achieved with aerosol droplets comprising superparamagnetic iron oxide nanoparticles—so-called nanomagnetosols—in combination with a target-directed magnetic gradient field. We suggest that nanomagnetosols may be useful for treating localized lung disease, by targeting foci of bacterial infection or tumour nodules.
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Acknowledgements
This work was supported by the German Federal Ministry of Education and Research in the Nanotechnology (Nanomagnetomedicine) programme, grants 13N8539, 13N8535, 13N8537, and in part by the BioFuture programme (0311898).
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C.R., T.W., A.F. and J.R. conceived and designed the experiments. P.D., B.G., K.H. and N.S. performed the experiments. P.D., C.R., A.F. and B.G. analysed the data. F.W., D.E., L.T., I.B. and C.B. contributed materials and analysis tools. C.R., P.D., T.W., B.G., A.F. and J.R. co-wrote the paper. All authors discussed the results and commented on the manuscript. P.D. and B.G. equally contributed to the work.
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Dames, P., Gleich, B., Flemmer, A. et al. Targeted delivery of magnetic aerosol droplets to the lung. Nature Nanotech 2, 495–499 (2007). https://doi.org/10.1038/nnano.2007.217
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DOI: https://doi.org/10.1038/nnano.2007.217
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