A multilaboratory study attempts to dispel some of the notions of the irreproducibility of mass spectrometry–based proteomics by pinpointing where the methodological problems are and where challenges remain.
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References
Bell, A.W. et al. Nat. Methods advance online publication, doi:10.1038/nmeth.1333 (17 May 2009).
Picotti, P., Aebersold, R. & Domon, B. Mol. Cell. Proteomics 6, 1589–1598 (2007).
Brunner, E. et al. Nat. Biotechnol. 25, 576–583 (2007).
de Godoy, L.M. et al. Nature 455, 1251–1254 (2008).
Baerenfaller, K. et al. Science 320, 938–941 (2008).
Aebersold, R. Nature 422, 115–116 (2003).
Kuster, B., Schirle, M., Mallick, P. & Aebersold, R. Nat. Rev. Mol. Cell Biol. 6, 577–583 (2005).
Domon, B. & Aebersold, R. Science 312, 212–217 (2006).
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Aebersold, R. A stress test for mass spectrometry–based proteomics. Nat Methods 6, 411–412 (2009). https://doi.org/10.1038/nmeth.f.255
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DOI: https://doi.org/10.1038/nmeth.f.255
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