Granulysin, a powerful cytolytic protein secreted from immune cells, underlies an extreme and deadly response to common medications, in which the skin blisters and sloughs off. The findings may also have implications for bone marrow transplant recipients suffering from graft-versus-host disease (pages 1343–1350).
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Nickoloff, B. Saving the skin from drug-induced detachment. Nat Med 14, 1311–1313 (2008). https://doi.org/10.1038/nm1208-1311
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DOI: https://doi.org/10.1038/nm1208-1311