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A sweeter life for diabetics?

Monitoring blood glucose is a painful ritual for diabetics. Now, however, noninvasive measurement is possible (pages 1198–1201).

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References

  1. The Diabetes Control and Complications Trial Research Group. New Engl. J. Med. 329, 977–986 (1993).

  2. O'Driscoll, C. Injecting new ideas. Chem. Brit. 30, 878–880 (1994).

    Google Scholar 

  3. Heller, J. The use of enzyme-substrate reactions in the design of self-regulated drug delivery systems. in Pulsatile Drug Delivery, Current Applications and Future Trends (eds Gurny, R., Junginger, H.E. & Peppas, N.A.) 57–71 (Wissenschaftliche Verlagsgesellschaft, Stuttgart, 1993).

    Google Scholar 

  4. Tamada, J.A., Bohannon, N.J.V., Potts, R.O. Measurement of glucose in diabetic subjects using noninvasive transdermal extraction. Nature Med., 1, 1198–1201 (1995).

    Article  CAS  Google Scholar 

  5. Burnette, R.R., Iontophoresis. in Transdermal Drug Delivery: Developmental Issues and Research initiatives, (eds Hadgraft, J., Guy, R.H.) 247–291 (Marcel Dekker, New York, 1989).

    Google Scholar 

  6. Leduc, S. Les Ions et les médications ioniques. (Masson, Paris, 1907).

    Book  Google Scholar 

  7. Pikal, M.J. The role of electroosmotic flow in transdermal iontophoresis. Adv. Drug Deliv. Rev. 9, 201–237 (1992).

    Article  CAS  Google Scholar 

  8. Glikfeld, P., Hinz, R.S. & Guy, R.H. Noninvasive sampling of biological fluids by iontophoresis. Pharmac. Res. 6, 988–990 (1989).

    Article  CAS  Google Scholar 

  9. Rao, G., Glikfeld, P. & Guy, R.H. Reverse iontophoresis: Development of a noninvasive approach for glucose monitoring. Pharmac. Res. 10, 1751–1755 (1993).

    Article  CAS  Google Scholar 

  10. Santi, P. & Guy, R.H. Reverse iontophoresis — Parameters determining electroosmotic flow: I. pH and ionic strength. J. Control. Release (in the press).

  11. Rao, G. et al. Reverse iontophoresis: Noninvasive glucose monitoring in vivo in humans. Pharmac. Res. (in the press).

  12. Guy, R.H. et al. Method for the iontophoretic non-invasive determination of the in vivo concentration level of an inorganic or organic substance. U.S. Patent # 5,362,307 (1994).

  13. Turner, A.P.F. (ed.) Chemical Sensors for In Vivo Monitoring. (JAI Press, London, 1993).

    Google Scholar 

  14. Ledger, P.W. Skin biological issues in electrically enhanced transdermal delivery. Adv. Drug Deliv. Rev. 9, 289–307 (1992).

    Article  CAS  Google Scholar 

  15. Amato, I. Race quickens for non-stick blood monitoring technology. Science 258, 892–893 (1992).

    Article  Google Scholar 

  16. Mitragotri, S., Blankschtein, D. & Langer, R. Ultrasound-mediated transdermal protein delivery. Science 269, 850–853 (1995).

    Article  CAS  Google Scholar 

  17. Tachibana, K. Transdermal delivery of insulin to alloxan-diabetic rabbits by ultrasound exposure. Pharmac. Res. 9, 952–954 (1992).

    Article  CAS  Google Scholar 

Download references

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Guy, R. A sweeter life for diabetics?. Nat Med 1, 1132–1133 (1995). https://doi.org/10.1038/nm1195-1132

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