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TH-17 differentiation: of mice and men

Nature Immunology volume 8, pages 903–905 (2007)Cite this article

A new subset of interleukin 17–producing CD4+ helper T cells with diverse functions has now been identified. New work by three groups substantially broadens the understanding of these cells in both mice and humans.

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Figure 1: T cell lineage commitment in humans versus mice.

Katie Ris-Vicari

References

  1. Acosta-Rodriguez, E.V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. Nat. Immunol. 8, 942–949 (2007).

    Article  CAS  Google Scholar 

  2. Wilson, N.J. et al. Nat. Immunol. 8, 950–957 (2007).

    Article  CAS  Google Scholar 

  3. Brustle, A. et al. Nat. Immunol. 8, 958–966 (2007).

    Article  Google Scholar 

  4. Stockinger, B. & Veldhoen, M. Curr. Opin. Immunol. 19, 281–286 (2007).

    Article  CAS  Google Scholar 

  5. Weaver, C.T., Hatton, R.D., Mangan, P.R. & Harrington, L.E. Annu. Rev. Immunol. 25, 821–852 (2007).

    Article  CAS  Google Scholar 

  6. Laurence, A. et al. Immunity 26, 371–381 (2007).

    Article  CAS  Google Scholar 

  7. Korn, T. et al. Nature advance online publication, 26 July 2007 (doi:10.1038/nature05970) (2007).

  8. Nurieva, R. et al. Nature advance online publication, 26 July 2007 (doi:10.1038/nature05969) (2007).

  9. Zhou, L. et al. Nat. Immunol. advance online publication, 20 June 2007 (doi:10.1038/ni1488) (2007).

  10. Mucida, D. et al. Science 317, 256–260 (2007).

    Article  CAS  Google Scholar 

  11. Mittrucker, H.W. et al. Science 275, 540–543 (1997).

    Article  CAS  Google Scholar 

  12. Acosta-Rodriguez, E.V. et al. Nat. Immunol. 8, 639–646 (2007).

    Article  CAS  Google Scholar 

  13. Amadi-Obi, A. et al. Nat. Med. 13, 711–718 (2007).

    Article  CAS  Google Scholar 

  14. Xu, L., Kitani, A., Fuss, I. & Strober, W. J. Immunol. 178, 6725–6729 (2007).

    Article  CAS  Google Scholar 

  15. Chen, Z., Tato, C.M., Muul, L., Laurence, A., & O'Shea, J.J. Arthritis Rheum. (in the press).

Download references

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Authors and Affiliations

  1. Arian Laurence and John J. O'Shea are with the Molecular Immunology and Inflammation Branch of the National Institutes of Health, National Institute of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA. osheajo@mail.nih.gov,

    Arian Laurence & John J O'Shea

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  1. Arian Laurence
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  2. John J O'Shea
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Laurence, A., O'Shea, J. TH-17 differentiation: of mice and men. Nat Immunol 8, 903–905 (2007). https://doi.org/10.1038/ni0907-903

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