An ancestor of the Chinese hamster ovary cell lines used for production of recombinant therapeutics has been sequenced.
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References
Xu, X. et al. Nat. Biotechnol. 29, 735–741 (2011).
Puck, T.T., Cieciura, S.J. & Robinson, A. J. Exp. Med. 108, 945–956 (1958).
Urlaub, G. & Chasin, L. Proc. Natl. Acad. Sci. USA 77, 4216–4220 (1980).
Urlaub, G., Käs, E., Carothers, A.M. & Chasin, L.A. Cell 33, 405–412 (1983).
Wurm, F.M. et al. Methotrexate and CHO cells: productivity and genetics of amplified expression vector sequences. in Production of Biologicals from Animal Cells in Culture (eds. Spier, R.E., Griffiths, J.B. & Meignier, B.) 316–326 (Butterworths, Oxford, 1990).
Deaven, L.L. & Petersen, D.F. Chromosoma 41, 129–144 (1973).
Kao, F.-T. & Puck, T.T. Nature 228, 329–332 (1970).
Derouazi, M. et al. Biochem. Biophys. Res. Commun. 340, 1069–1077 (2006).
Hsu, T.C. Int. Rev. Cytol. 12, 69–161 (1961).
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Wurm, F., Hacker, D. First CHO genome. Nat Biotechnol 29, 718–720 (2011). https://doi.org/10.1038/nbt.1943
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DOI: https://doi.org/10.1038/nbt.1943
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