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Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses

Nature Medicine volume 4, pages 365–368 (1998)Cite this article

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References

  1. Pardoll, D. & Beckerieg, A.M. Exposing the immunology of naked DNA vaccines. Immunity 3, 165–169 (1995).

    Article  CAS  Google Scholar 

  2. McDonnell, W.M. & Askari, F.K. DNA vaccines. New Engl. J. Med. 334, 42–45 (1996).

    Article  CAS  Google Scholar 

  3. Corr, M., Lee, D.J., Carson, D.A. & Tighe, H. +Gene vaccination with naked plasmid DNA: Mechanism of CTL priming. J. Exp. Med. 184, 1555–1560 (1996).

    Article  CAS  Google Scholar 

  4. Doe, B., Selby, M., Barnett, S., Baenziger, J. & Walker, C. Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow derived cells. Proc. Natl. Acad. Sci. USA 93, 8578–8583 (1996).

    Article  CAS  Google Scholar 

  5. Iwasaki, A., Torres, C.A.T., Ohashi, P.S., Robinson, H.L. & Barber, B.H.J. The dominant role of bone marrow derived cells in CTL induction following plasmid DNA immunization at different sites. Immunology 159, 11–14 (1997).

    CAS  Google Scholar 

  6. Okada, H. & Toguchi, H. Biodegradable microspheres in drug delivery. Crit. Rev. Ther. Drug Carrier Sys. 12, 1–99 (1995).

    Article  CAS  Google Scholar 

  7. Tabata, Y. & Ikada, Y. Phagocytosis of polymer microspheres by macrophages. Adv. Polymer Sci. 94, 107–141 (1990).

    Article  CAS  Google Scholar 

  8. Kanke, M., Geissler, R.G., Powell, D., Kaplan, A. & DeLuca, P.P.J. Interaction of microspheres with blood constituents. III. Macrophage phagocytosis of various types of polymeric drug carriers. Parenteral Sci. Technol. 42, 157–165 (1988).

    CAS  Google Scholar 

  9. Carbone, F.R. & Bevan, M.J. Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization. J. Exp. Med. 169, 603–612 (1989).

    Article  CAS  Google Scholar 

  10. Vitiello, A. et al. Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. J. Clin. Invest. 95, 341–349 (1995).

    Article  CAS  Google Scholar 

  11. Fayolle, C., et al. Induction of cytotoxic T-cell response by optimal length peptides does not require CD4+ T-cell help. Immunology 89, 41–45 (1996).

    Article  CAS  Google Scholar 

  12. Anton, L.C., Yewdall, J.W. & Bennink, J.R. MHC-class I associated peptides produced from endogenous gene products with vastly different efficiencies. J. Immunol. 158, 2535–2542 (1997).

    CAS  PubMed  Google Scholar 

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Author notes

  1. Joanne Curley

    Present address: Incyte Pharmaceuticals, 1060 East Meadow Circle, Palo Alto, California, 94303, USA

Authors and Affiliations

  1. Pangaea Pharmaceuticals Inc., 763E Concord Avenue, Cambridge, Massachusetts, 02138, USA

    Mary Lynne Hedley & Robert Urban

  2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Joanne Curley

Authors
  1. Mary Lynne Hedley
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  2. Joanne Curley
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  3. Robert Urban
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Hedley, M., Curley, J. & Urban, R. Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses. Nat Med 4, 365–368 (1998). https://doi.org/10.1038/nm0398-365

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