Abstract
PROSTAGLANDINS E and F have a strong and opposite effect on airway smooth muscle1,2. They are released from the isolated guinea-pig lung during anaphylaxis3 and injection of histamine or acetylcholine into the pulmonary circulation4, both circumstances where airway constriction probably occurs. Therefore, airway tone might be modulated by the prostaglandins released, if they reach the airway smooth muscle. We report that such modulation occurs in the isolated guinea-pig trachea.
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OREHEK, J., DOUGLAS, J., LEWIS, A. et al. Prostaglandin Regulation of Airway Smooth Muscle Tone. Nature New Biology 245, 84–85 (1973). https://doi.org/10.1038/newbio245084a0
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DOI: https://doi.org/10.1038/newbio245084a0
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