Although gene therapy studies of angiogenesis have focused on the ability of endothelial cells to form new structures, it has recently become clear that the subsequent stages of remodeling are crucial to attaining stable and functional vessels. A precise balance of cell types and molecules is required for normal vessel maturation and must be considered in the design of therapeutic angiogenic strategies.
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Blau, H., Banfi, A. The well-tempered vessel. Nat Med 7, 532–534 (2001). https://doi.org/10.1038/87850
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DOI: https://doi.org/10.1038/87850
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