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Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci

Abstract

We have carried out a genome screen for atopic dermatitis (AD) and have identified linkage to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity.

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Acknowledgements

We thank J.A. Faux for IgE estimations and L.R. Cardon for helpful comments on the linkage analyses. This study was funded by the Wellcome Trust.

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Correspondence to William O.C.M. Cookson.

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Cookson, W., Ubhi, B., Lawrence, R. et al. Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci. Nat Genet 27, 372–373 (2001). https://doi.org/10.1038/86867

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