In addition to the TCR and classical MHC class I, MHC class 1–like molecules can interact with a variety of receptors that play a role in T cell activation. Engagement of NKG2D on CMV-specific αβ CD8+ cells by MIC was found to provide them with a costimulatory signal and augment their cytotoxic response.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Groh, V. et al. Nature Immunol. 2, 255–260 (2001).
Bahram, S., Bresnahan, M., Geraghty, D. E. & Spies, T. Proc. Natl Acad. Sci. USA 91, 6259–63 (1994).
Groh, V. et al. Proc. Natl Acad. Sci. USA 96, 6879–84 (1999).
Bauer, S. et al. Science 285, 727–729 (1999).
Diefenbach, A., Jamieson, A. M., Liu, S. D., Shastri, N. & Raulet, D. H. Nature Immunol. 1, 119–126 (2000).
Chalupny, J. et al. FASEB J 14, 1018 (2000).
Cerwenka, A. et al. Immunity 12, 721–727 (2000).
Ding, Y., Sumitran, S. & Holgersson, J. Scand. J. Immunol. 49, 459–65 (1999).
Watts, T. H. & DeBenedette, M. A. Curr. Opin. Immunol. 11, 286–93 (1999).
Wu, J. et al. Science 285, 730–732 (1999).
Wu, J., Cherwinski, H., Spies, T., Phillips, J. H. & Lanier, L. L. J. Exp. Med. 192, 1059–68 (2000).
Groh, V., Steinle, A., Bauer, S. & Spies, T. Science 279, 1737–1740 (1998).
Dechanet, J. et al. J. Clin. Invest. 103, 1437–49 (1999).
Mandelboim, O. et al. Science 274, 2097–2100 (1996).
Nameka, T. et al. J. Immunol. 165, 1138–1145 (2000).
Ugolini, S. & Vivier, E. Curr. Opin. Immunol. 12, 295–300 (2000).
Long, E. O. Annu. Rev. Immunol. 17, 875–904 (1999).
Moretta, A., Biassoni, R., Bottino, C., Mingari, M. C. & Moretta, L. Immunol. Today 21, 228–234 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ugolini, S., Vivier, E. Multifaceted roles of MHC class I and MHC class I–like molecules in T cell activation. Nat Immunol 2, 198–200 (2001). https://doi.org/10.1038/85246
Issue Date:
DOI: https://doi.org/10.1038/85246
This article is cited by
-
Amino‐acid sequence motifs for PKC‐mediated membrane trafficking of the inhibitory killer Ig‐like receptor
Immunology & Cell Biology (2008)
-
Activation‐induced upregulation of inhibitory killer Ig‐like receptors is regulated by protein kinase C
Immunology & Cell Biology (2007)
-
MHC class Ib molecules bridge innate and acquired immunity
Nature Reviews Immunology (2005)
-
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
Nature (2003)