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Exploring the new world of the genome with DNA microarrays

Nature Genetics volume 21, pages 33–37 (1999)Cite this article

Abstract

Thousands of genes are being discovered for the first time by sequencing the genomes of model organisms, an exhilarating reminder that much of the natural world remains to be explored at the molecular level. DNA microarrays provide a natural vehicle for this exploration. The model organisms are the first for which comprehensive genome–wide surveys of gene expression patterns or function are possible. The results can be viewed as maps that reflect the order and logic of the genetic program, rather than the physical order of genes on chromosomes. Exploration of the genome using DNA microarrays and other genome–scale technologies should narrow the gap in our knowledge of gene function and molecular biology between the currently–favoured model organisms and other species.

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Figure 1: Gene expression analysis using a DNA microarray.
Figure 2: A gene expression map of the yeast genome.
Figure 3: The yeast cell–cycle 'phaseogram'; gene expression during the yeast cell cycle.

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Authors and Affiliations

  1. Department of Biochemistry, Stanford University School of Medicine, Stanford, 94305, California, USA

    Patrick O. Brown

  2. Department of Genetics, Stanford University School of Medicine, Stanford, 94305, California, USA

    David Botstein

  3. Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, 94305, California, USA

    Patrick O. Brown

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  1. Patrick O. Brown
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  2. David Botstein
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Brown, P., Botstein, D. Exploring the new world of the genome with DNA microarrays. Nat Genet 21 (Suppl 1), 33–37 (1999). https://doi.org/10.1038/4462

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