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Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domains

Nature volume 368, pages 520–525 (1994)Cite this article

Abstract

A puzzling property of the transcriptional activators encoded by several animal viruses is their ability to function promiscuously. The adenovirus E1a protein, for example, stimulates transcription of adenoviral genes as well as a wide variety of other viral and cellular genes. We show that E1a can interact with several classes of cellular DNA-binding domains and thereby be recruited to diverse promoters. Our results explain how a single protein can regulate transcription of multiple genes that lack a common promoter element.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138, USA

    Fang Liu

  2. Program in Molecular Medicine, University of Massachusetts Medical Center, 373 Plantation Street, Worcester, Massachusetts, 01605, USA

    Fang Liu & Michael R. Green

Authors
  1. Fang Liu
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  2. Michael R. Green
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Liu, F., Green, M. Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domains. Nature 368, 520–525 (1994). https://doi.org/10.1038/368520a0

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