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S-nitrosylation: spectrum and specificity

Nitric oxide regulates a broad functional spectrum of proteins by S-nitrosylation. Specificity is conferred by acid–base and hydrophobic motifs that target critical cysteine residues and by protein–protein interactions that confine the signals in space.

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Figure 1: Mechanisms and motifs for S-nitrosylation.

References

  1. Stamler, J. S. Cell 78, 931–936 ( 1994).

    Article  CAS  Google Scholar 

  2. Stamler, J. S., Toone, E. J., Lipton, S. A. & Sucher, N. J. Neuron 18, 691–696 ( 1997).

    Article  CAS  Google Scholar 

  3. Stamler, J.S et al. Science 276, 2034– 2037 (1997).

    Article  CAS  Google Scholar 

  4. Eu, J. P., Sun, J., Xu, L., Stamler, J. S. & Meissner, G. Cell 102, 499– 509 (2000).

    Article  CAS  Google Scholar 

  5. Choi, Y-B. et al. Nature Neurosci. 3, 15– 21 (2000).

    Article  CAS  Google Scholar 

  6. Pérez-Mato, I., Castro, C., Ruiz, F. A., Corrales, F. J. & Mato, J. M. J. Biol. Chem. 274, 17075– 17079 (1999).

    Article  Google Scholar 

  7. Mannick, J. B. et al. Science 284, 651–654 (1999).

    Article  CAS  Google Scholar 

  8. Jaffrey, S. R., Erdjument-Bromage, H., Ferris, C. D., Temps, P. & Snyder, S. H. Nature Cell Biol. 3, 193–197 (2001).

    Article  CAS  Google Scholar 

  9. Xu, L., Eu, J. P., Meissner G & Stamler J. S. Science 279, 234–237 (1998).

    Article  CAS  Google Scholar 

  10. Lander, H. M. et al. J. Biol. Chem. 272, 4323– 4326 (1997).

    Article  CAS  Google Scholar 

  11. Broillet, M-C. J. Biol. Chem. 275, 15135–15141 (2000).

    Article  CAS  Google Scholar 

  12. Marshall, H. E., Merchant, K. & Stamler, J. S. FASEB J. 14, 1889– 1900 (2000).

    Article  CAS  Google Scholar 

  13. Park, H-S., Huh, S-H., Kim, M-S., Lee, S. H. & Choi, E-J. Proc. Natl Acad. Sci. USA 97, 14382 –14387 (2000).

    Article  CAS  Google Scholar 

  14. Verbavatz, J-M., Combet, S., Devuyst, O. & Balligand, J-L. Circulation 102, II–157 ( 2000).

    Google Scholar 

  15. Hess, D. T., Patterson, S. I., Smith, D. S. & Skene, J. H. P. Nature 366, 562–565 ( 1993).

    Article  CAS  Google Scholar 

  16. Moore, C. P., Zhang, J-Z. & Hamilton, S. L. J. Biol. Chem. 274, 36831– 36834 (1999).

    Article  CAS  Google Scholar 

  17. Moore, C. P. et al. Biochemistry 38, 8532– 8537 (1999).

    Article  CAS  Google Scholar 

  18. Liu, X., Miller, M. J. S., Joshi, M. S., Thomas, D. D. & Lancaster, J. R. Jr Proc. Natl Acad. Sci. USA 95, 2175–2179 ( 1998).

    Article  CAS  Google Scholar 

  19. Nedospasov, A., Rafikov, R., Beda, N. & Nudler, E. Proc. Natl Acad. Sci. USA 97, 13543–13548 (2000).

    Article  CAS  Google Scholar 

  20. Chu, K., et al. Nature 403, 921–923 (2000).

    Article  CAS  Google Scholar 

  21. Kone, B. C. Acta Physiol. Scand. 168, 27–31 (2000).

    Article  CAS  Google Scholar 

  22. Fang, M. et al. Neuron 28, 183–193 (2000).

    Article  CAS  Google Scholar 

  23. Sattler, R. et al. Science 284, 1845– 1848 (1999).

    Article  CAS  Google Scholar 

Download references

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Hess, D., Matsumoto, A., Nudelman, R. et al. S-nitrosylation: spectrum and specificity. Nat Cell Biol 3, E46–E48 (2001). https://doi.org/10.1038/35055152

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