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Induction and regulation of the IgE response

Nature volume 402, pages 18–23 (1999)Cite this article

Abstract

Immunoglobulin E (IgE) is believed to be one of the major mediators of immediate hypersensitivity reactions that underlie atopic conditions such as urticaria, seasonal allergy, asthma and anaphylaxis. Factors that control IgE production are therefore essential to the pathogenesis of these important afflictions. But a complete understanding of this topic is lacking, while new data have raised questions regarding the precise role of IgE in atopic disease. Evolving concepts of IgE production and elimination are likely to clarify the importance of IgE in health and disease.

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Figure 1: The type 1 hypersensitivity reaction.
Figure 2: Overview of T-cell differentiation.
Figure 3: Molecular control of the IgE response.
Figure 4: Elimination of IgE by extracellular transport.
Figure b1

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Notes

  1. *Terms in italic are defined in the glossary on p. 39.

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    David B. Corry & Farrah Kheradmand

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Corry, D., Kheradmand, F. Induction and regulation of the IgE response. Nature 402 (Suppl 6760), 18–23 (1999). https://doi.org/10.1038/35037014

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