Abstract
TOLERANCE to self-antigens has been shown to develop during ontogeny as a result of the elonal deletion of self-reactive T cells1–4. Tolerance, or better 'nonresponsiveness', to specific antigens can also be induced in adult animals5–9 but the mechanism(s) involved are not well understood10. Most murine T-helper cells that express the Vβ6 T-cell receptor gene segment are specific for Mls-1a antigens3. We have therefore been able to use an anti-Vβ6 monoclonal antibody to follow the fate of Mls-1a specific T cells in adult Mls-1b mice made specifically unresponsive to Mls-1a. We show that the induced unresponsiveness is not due to elonal deletion, but rather to elonal anergy. The anergic Vβ6 T-helper cells express IL-2 receptors and undergo limited blastogenesis in vitro upon stimulation, but do not produce IL-2, in marked contrast to Vβ6 cells from naive mice. Our data appear to represent an in vivo correlate for the induction of anergy that has been observed in T-cell lines in vitrol l–15.
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References
Kappler, J. W., Roehm, N. & Marrack, P. Cell 49, 273–280 (1987).
Kappler, J. W., Staerz, U., White, J. & Marrack, P. C. Nature 332, 35–40 (1988).
MacDonald, H. R. et al. Nature 40–45 (1988).
Kisielow, P., Blüthmann, H., Staerz, U. D., Steinmetz, M. & von Boehmer, H. Nature 333, 742–746 (1988).
Jacobson, J., Lilliehöök, B. & Blomgren, H. Scand. J. Immun. 4, 181–191 (1975).
Lilliehöök, B., Jacobson, H. & Blomgren, H. Scand. J. Immun. 4, 209–216 (1975).
Miller, S. D., Sy, M.-S. & Claman, H. N. Eur. J. Immunol. 7, 165–170 (1977).
Brondz, B. D., Karanlov, A. V., Abronina, I. F. & Blandova, L. K. Scand. J. Immun. 13, 517–534 (1981).
Jenkins, M. K. & Schwartz, R. H. J. exp. Med. 165, 302–319 (1987).
von Boehmer, H., Teh, H. S. & Kisielow, P. Immun. Today 10, 577–61 (1989).
Markmann, J. et al. Nature 336, 476–479 (1988).
Lamb, J. R. et al. J. exp. Med. 157, 1434–1447 (1983).
Lamb, J. R. & Feldmann, M. Nature 308, 72–74 (1984).
Quill, H. & Schwartz, R. H. J. Immun. 138, 3704–3712 (1987).
Jenkins, M. K., Pardoll, D. M., Mizuguchi, J., Chused, T. M. & Schwartz, R. H. Proc. natn. Acad. Sci. U.S.A. 84, 5409–5413 (1987).
Festenstein, H. Transplantn Rev. 15, 62–88 (1973).
Abe, R. & Hodes, R. J. Immun. Today 9, 230–235 (1988).
Halle-Pannenko, O., Pritchard, L. L. & Bruley-Rosset, M. Eur. J. Immun. 17, 1751–1755 (1987).
von Boehmer, H. & Schubiger, K. Eur. J. Immun. 14, 1048–1052 (1984).
Ready, A. R., Jenkinson, E. J., Kingston, R. & Owen, J. J. I. Nature 310, 231–233 (1984).
Flajnik, M. F., DuPasquier, L. & Cohen, N. Eur. J. Immun. 15, 540–547 (1985).
Ohki, H., Martin, C., Corbel, C., Coltey, M. & Le Douarin, N. M. Science 237, 1032–1035 (1987).
Marrack, P. et al. Cell 53, 627–634 (1988).
Nossal, G. J. V. & Pike, B. L. Proc. natn. Acad. Sci. U.S.A. 77, 1602–1606 (1980).
Goodnow, C. C. et al. Nature 334, 676–682 (1988).
Janeway, C. A., Jr., Fischer-Lindahl, K. & Hämmerling, U. Immun. Today 9, 125–126 (1988).
Payne, J. et al. Proc. natn. Acad. Sci. U.S.A. 85, 7695–7698 (1988).
Dialynas, D. P. et al. J. Immun. 131, 2445–2451 (1983).
Malek, T. R., Robb, R. J. & Shevach, E. M. Proc. natn. Acad. Sci. U.S.A. 80, 5694–5698 (1983).
Ceredig, R., Lowenthal, J. W., Nabholz, M. & MacDonald, H. R. Nature 314, 98–100 (1985).
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Rammensee, HG., Kroschewski, R. & Frangoulis, B. Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells. Nature 339, 541–544 (1989). https://doi.org/10.1038/339541a0
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DOI: https://doi.org/10.1038/339541a0
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