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Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells

Nature volume 333, pages 529–533 (1988)Cite this article

Abstract

A class I histocompatibility gene, H-2Kb, linked to the rat insulin promoter, is overexpressed in the pancreatic β cells of transgenic mice. The mice, whether syngeneic or allogeneic to the transgene, develop insulin dependent diabetes without detectable T cell infiltration, suggesting a direct, non-immune role for the transgenic class I molecules in the disease process.

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Authors and Affiliations

  1. The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Victoria, 3050, Australia

    Janette Allison, I. L. Campbell, G. Morahan, T. E. Mandel, L. C. Harrison & J. F. A. P. Miller

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  1. Janette Allison
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  2. I. L. Campbell
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  3. G. Morahan
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  4. T. E. Mandel
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  5. L. C. Harrison
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  6. J. F. A. P. Miller
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Allison, J., Campbell, I., Morahan, G. et al. Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells. Nature 333, 529–533 (1988). https://doi.org/10.1038/333529a0

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