Abstract
T lymphocytes reactive with the product of the Mlsa-allele of the minor lymphocyte stimulating (Mls) locus use a predominant T-cell receptor β-chain variable gene segment (Vβ6). Such Vβ6-bearing T cells are selectively eliminated in the thymus of Mlsa-bearing mice, consistent with a model in which tolerance to self antigens is achieved by clonal deletion.
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References
Kronenberg, M., Siu, G., Hood, L. E. & Shastri, N. A. Rev. Immun. 4, 529–591 (1986).
Nossal, G. J. V. A. Rev. Immun. 1, 33–62 (1983).
Zinkernagel, R. & Doherty, P. C. Adv. Immun. 27, 51–77 (1979).
Kappler, J. W. et al. Cell 49, 263–271 (1987).
Kappler, J. W., Roehm, N. & Marrack, P. Cell 49, 273–280 (1987).
Rupp, F., Acha-Orbea, H., Hengartner, H., Zinkernagel, R. & Joho, R. Nature 315, 425–427 (1985).
Garman, R., Ko, J.-L., Vulpe, C. & Raulet, D. Proc natn. Acad. Sci. U.S.A. 83, 3987–3991 (1986).
Fink, P. J., Matis, L. A., McElligott, D. L., Bookman, M. & Hedrick, S. M. Nature 321, 219–226 (1986).
Winoto, A. et al. Nature 324, 679–682 (1986).
Rupp, F. et al. Proc. natn. Acad. Sci. U.S.A. 84, 219–222 (1987).
Goverman, J. et al. Cell 40, 859–867 (1985).
Iwamoto, A. et al. J. exp. Med. 165, 591–600 (1987).
Morel, P., Livingstone, A. M. & Fathman, C. G. J. exp. Med. 166, 583–588 (1987).
Festenstein, H. Transplantn Rev. 15, 62–88 (1973).
Janeway, C. A., Lerner, E. A., Jason, J. M. & Jones, B. Immunogenetics 10, 481–497 (1980).
Lutz, C. A., Glasebrook, A. L. & Fitch, F. W. Eur. J. Immun. 11, 726–734 (1981).
Kronke, M., Scheurich, P., Pfizenmaier, K., Röllinghopf, M. & Wagner, H. J. exp. Med. 156, 41–54 (1982).
Miller, R. A. & Stutman, O. J. Immun. 128, 2258–2264 (1982).
Acha-Orbea, H., Zinkernagel, R. M. & Hengartner, H. Eur. J. Immun. 15, 31–36 (1985).
Hengartner, H. et al. (in preparation).
Haskins, K. et al. J. exp. Med. 160, 452–471 (1984).
Behlke, M. A. et al. J. exp. Med. 165, 257–262 (1987).
Roehm, N. et al. Cell 38, 577–584 (1984).
Ceredig, R., Dialynas, D. P., Fitch, F. W. & MacDonald, H. R. J. exp. Med. 158, 1654–1671 (1983).
Sim, G. K. & Augustin, A. A. Cell 42, 89–92 (1985).
Festenstein, H. & Berumen, L. Transplantation 37, 322–324 (1984).
Abe, R., Ryan, J. J. & Hodes, R. J. J. exp. Med. 165, 1113–1129 (1987).
Click, R. E. et al. J. Immun. 139, 321–325 (1987).
Abe, R., Ryan, J. J. & Hodes, R. J. J. exp. Med. 166, 1150–1155 (1987).
Festenstein, H., Bishop, C. & Taylor, B. A. Immunogenetics 5, 357–361 (1977).
Tonkonogy, S. L. & Winn, H. J. J. Immun. 116, 835–841 (1976).
Kimura, S., Tada, N., Nakayama, E., Liu, Y. & Hammerling, U. Immunogenetics 14, 3–14 (1981).
Wall, K. A., Lorber, M. I., Loken, M. R., McClatchey, S. & Fitch, F. W. J. Immun. 131, 1056–1064 (1983).
Macphail, S. & Stutman, O. Eur. J. Immun. 14, 318–324 (1984).
Janeway, C. A. & Katz, M. E. J. Immun. 134, 2057–2063 (1985).
Peck, A. B., Janeway, C. A. & Wigzell, H. Nature 266, 840–842 (1977).
Molnar-Kimber, K. & Sprent, J. J. exp. Med. 151, 407–417 (1980).
Lynch, D. H. et al. J. Immun. 134, 2071–2078 (1985).
Katz, M. E. & Janeway, C. A. J. Immun. 134, 2064–2070 (1985).
Kourilsky, P. & Claverie, J.-M. Ann. Inst. Pasteur/ Immun. 137D, 3–21 (1986).
Blackman, M. et al. Cell 47, 349–357 (1986).
Macphail, S. et al. J. Immun. 135, 2967–2974 (1985).
Festenstein, H. Transplantation 18, 555–557 (1974).
Jones, B. & Janeway, C. A. Immunogenetics 16, 243–255 (1982).
Cerottini, J.-C., Engers, H. D., MacDonald, H. R. & Brunner, K. T. J. exp. Med. 140, 703–717 (1974).
MacDonald, H. R., Engers, H. D., Cerottini, J.-C. & Brunner, K. T. J. exp. Med. 140, 718–730 (1974).
MacDonald, H. R., Blanc, C., Lees, R. K. & Sordat, B. J. Immun. 136, 4337–4339 (1986).
Heitzmann, H. & Richards, R. M. Proc. natn. Acad. Sci. U.S.A. 71, 3537–3541 (1984).
Oi, V. T., Glazer, A. N. & Stryer, L. J. Cell Biol. 93, 981–986 (1982).
MacDonald, H. R. & Zaech, P. Cytometry 3, 55–58 (1982).
Ceredig, R., Lowenthal, J. W., Nabholz, M. & MacDonald, H. R. Nature 314, 98–100 (1985).
Nabholz, M. et al. Immun. Rev. 51, 125–156 (1980).
Leo, O., Foo, M., Sachs, D. H., Samelson, L. E. & Bluestone, J. A. Proc. natn. Acad. Sci. U.S.A. 84, 1374–1378 (1987).
Landegren, U. J. Immun. Meth. 67, 379–488 (1984).
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MacDonald, H., Schneider, R., Lees, R. et al. T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens. Nature 332, 40–45 (1988). https://doi.org/10.1038/332040a0
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DOI: https://doi.org/10.1038/332040a0
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