Abstract
Evidence is provided for the existence of a seventh gene in the genome of human T-lymphotropic virus type III/lymphadenopathy-associated virus. The gene is necessary for replication and acts post-transcriptionally to relieve negative regulation of the messenger RNA for the virion capsid and envelope proteins. These observations suggest mechanisms for regulating both the latent and lytic phases of the virus life cycle.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Barre-Sinoussi, F. et al. Science 220, 868–871 (1983).
Broder, S. M. & Gallo, R. C. New Engl. J. Med. 311, 1292–1297 (1984).
Gallo, R. C. et al. Science 224, 497–500 (1984).
Popovic, M., Sarngadharan, M. G., Read, E. & Gallo, R. C. Science 225, 497–500 (1984).
Sarngadharan, M. G., Popovic, M., Bruch, L., Shupbach, J. & Gallo, R. C. Science 224, 506–508 (1984).
Seligman, M. et al. New Engl. J. Med. 311, 1286–1292 (1984).
Shaw, G. M. et al. Science 227, 177–182 (1985).
Zagury, D. et al. Science 231, 850–853 (1986).
Ratner, L. et al. Nature 313, 277–284 (1985).
Wain-Hobson, S., Sonigo, P., Danos, O., Cole, S. & Alizon, M. Cell 40, 9–19 (1985).
Sanchez-Pescador, R. et al. Science 227, 484–492 (1985).
Muesing, M. A. et al. Nature 313, 450–458 (1985).
Robey, W. G. et al. Science 228, 593–596 (1985).
Veronese, F. et al. Science 229, 1402–1405 (1985).
Kitchen, L. et al. Nature 312, 367–370 (1984).
Schupbach, J. et al. Science 228, 503–505 (1984).
Allan, J. S. et al. Science 228, 1091–1093 (1985).
Arya, S., Guo, C., Josephs, S. F. & Wong-Staal, F. Science 229, 69–74 (1985).
Sodroski, J., Patarca, R., Rosen, C., Wong-Staal, F. & Haseltine, W. A. Science 229, 74–77 (1985).
Sodroski, J. et al. Science 231, 1549–1553 (1985).
Lee, T. H. et al. Science 231, 1546–1549 (1985).
Allan, J. S. et al. Science 230, 810–812 (1985).
Goh, W. C., Rosen, C., Sodroski, J., Ho, D. & Haseltine, W. A. J. Virol. (in the press).
Rosen, C. A. et al. Nature 319, 555–559 (1986).
Sodroski, J. G. et al. Science 227, 171–173 (1985).
Rosen, C. A., Sodroski, J. G. & Haseltine, W. A. Cell 41, 813–823 (1985).
Dayton, A., Sodroski, J. G., Rosen, C. A., Goh, W. C. & Haseltine, W. A. Cell 44, 941–947 (1986).
Fisher, A. C., Collati, E., Ratner, L., Gallo, R. C. & Wong-Staal, F. Nature 316, 262–265 (1985).
Rosen, C. A., Sodroski, J. G., Campbell, K. & Haseltine, W. A. J. Virol. 57, 379–384 (1986).
Mulligan, R. C., Howard, B. H. & Berg, P. Nature 277, 108–114 (1979).
Queen, C. & Baltimore, D. Cell 33, 741–748 (1983).
Rho, H. M., Poiesz, B. J., Ruscetti, F. W. & Gallo, R. C. Virology 112, 355–360 (1981).
Lee, T. H. et al. Proc. natn. Acad. Sci. U.S.A. 81, 3856–3860 (1984).
Sodroski, J., Rosen, C. & Haseltine, W. Science 225, 381–384 (1984).
Gorman, C. M., Moffat, L. F. & Howard, B. H. Molec. cell. Biol. 2, 1044–1051 (1982).
Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J. & Rutter, W. J. Biochemistry 18, 5294–5299 (1979).
Thomas, P. Proc. natn. Acad. Sci. U.S.A. 77, 5201–5202 (1980).
Hopp, T. P. & Woods, K. R. Proc. natn. Acad. Sci. U.S.A. 78, 3824–3825 (1981).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sodroski, J., Goh, W., Rosen, C. et al. A second post-transcriptional trans-activator gene required for HTLV-III replication. Nature 321, 412–417 (1986). https://doi.org/10.1038/321412a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/321412a0
This article is cited by
-
Identification of a homogenous structural basis for oligomerization by retroviral Rev-like proteins
Retrovirology (2017)
-
Molecular characterization of HIV-1 genome in fission yeast Schizosaccharomyces pombe
Cell & Bioscience (2015)
-
Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA
Retrovirology (2014)
-
Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import
Retrovirology (2011)
-
Characterization of the HIV-1 RNA associated proteome identifies Matrin 3 as a nuclear cofactor of Rev function
Retrovirology (2011)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
