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Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection

Abstract

H–2 gene transfection was used to restore expression of H–2K antigens in metastatic and non-metastatic subclones of a murine fibrosarcoma that lack their major histocompatibility complex-encoded H–2K antigens. De novo expression of H–2K reduced tumorigenicity and abolished the formation of metastasis in syngeneic mice. Expression of H–2K may lead to effective recognition of the disseminating tumour cells by the host immune system.

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Wallich, R., Bulbuc, N., Hämmerling, G. et al. Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection. Nature 315, 301–305 (1985). https://doi.org/10.1038/315301a0

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