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Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor

Nature volume 306, pages 32–36 (1983)Cite this article

Abstract

The primary structures of two types of bovine brain substance P precursors have been determined. One precursor contains a sequence homologous to that of the amphibian peptide kassinin. This new tachykinin sequence is bounded by paired basic amino acids Lys-Arg, which suggests that, like substance P, it can be liberated from the precursor and may serve as an endogenous hormone or neuromediator in mammalian organisms.

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Authors and Affiliations

  1. Institute for Immunology, Kyoto University Faculty of Medicine, Kyoto, 606, Japan

    Hiroyuki Nawa & Shigetada Nakanishi

  2. Pharmaceutical Institute, Keio University School of Medicine, Tokyo, 160, Japan

    Tadaaki Hirose, Hideaki Takashima & Seiichi Inayama

Authors
  1. Hiroyuki Nawa
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  2. Tadaaki Hirose
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  3. Hideaki Takashima
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  4. Seiichi Inayama
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  5. Shigetada Nakanishi
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Nawa, H., Hirose, T., Takashima, H. et al. Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor. Nature 306, 32–36 (1983). https://doi.org/10.1038/306032a0

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