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Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

Nature volume 304, pages 35–39 (1983)Cite this article

Abstract

A partial amino acid sequence of human platelet-derived growth factor, the major mitogen in serum for cells of mesenchymal origin, has been determined. A region of 104 contiguous amino acids shows virtual identity with the predicted sequence of p28sis, the putative transforming protein of simian sarcoma virus (SSV). This similarity suggests a mechanism for transformation by SSV and other agents, involving expression of growth factors.

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Authors and Affiliations

  1. Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, London, WC2A 3PX, UK

    Michael D. Waterfield, Geoffrey T. Scrace, Nigel Whittle & Paul Stroobant

  2. Institute of Medical and Physiological Chemistry, University of Uppsala, Sweden

    Ann Johnsson, Åke Wasteson & Carl-Henrik Heldin

  3. Department of Pathology, University of Uppsala, Sweden

    Bengt Westermark

  4. Departments of Medicine and Biological Chemistry, Washington University School of Medicine, The Jewish Hospital of St Louis, Missouri, 63110, USA

    Jung San Huang & Thomas F. Deuel

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  1. Michael D. Waterfield
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Waterfield, M., Scrace, G., Whittle, N. et al. Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature 304, 35–39 (1983). https://doi.org/10.1038/304035a0

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