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Histamine plays a part in induction of drinking by food intake

Nature volume 302, pages 65–66 (1983)Cite this article

Abstract

Drinking occurs around meal time in most mammals. Food-related drinking accounts for ∼70% of daily fluid intake for rats1,2, but little is known of the mechanisms by which eating elicits drinking3. That eating4 and vagal stimulation5,6 elicit the release of histamine from gastric mucosa, together with the fact that drinking elicited by eating7 or exogenous histamine8–10 depends on an intact abdominal vagus, suggests a role for endogenous histamine as a component of food-related drinking in the rat. I report here that the combined antagonism of peripheral H1 and H2 receptors for histamine (1) attenuates drinking elicited by normal food-contingent stimulation of the gastrointestinal tract and (2) abolishes drinking elicited by pregastric food-contingent stimulation during sham feeding in the rat.

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  1. Department of Psychology, Colgate University, Hamilton, New York, 13346, USA

    F. Scott Kraly

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  1. F. Scott Kraly
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Kraly, F. Histamine plays a part in induction of drinking by food intake. Nature 302, 65–66 (1983). https://doi.org/10.1038/302065a0

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