Abstract
The finding1 that the turnover of the anionic phospholipid, phosphatidylinositol (PI), increases with increased synaptic activity has long stimulated interest in the possible functional roles of this phospholipid and its phosphorylated products, phosphatidylinositol 4,5-biphosphate (triphosphoinositide or TPI) and phosphatidyl-myoinositol 4-phosphate (diphosphoinositide or DPI)2. TPI metabolism is altered by a variety of cellular stimuli2, but no specific function of the lipid has been identified. However, in many instances (see, for example, refs 3–6) a correlation has been observed between changes in PI metabolism and membrane structure. We have recently correlated membrane macro-viscosity with the lateral mobility of membrane glycoproteins7, and have shown that 2,3-diphosphoglycerate (2,3-DPG), which is similar in structure to TPI, increases glycoprotein lateral mobility8. We now report that TPI also increases the lateral mobility of glycoproteins when added to erythrocyte membranes, and suggest that TPI acts similarly to other polyanions by disrupting the erythrocyte membrane skeleton.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hokin, L. M. & Hokin, M. R. Biochim. biophys. Acta 28, 102 (1955).
Michell, R. H. Trends biochem. Sci. 4, 128 (1979).
Allan, D. & Michell, R. H. Biochim. biophys. Acta 508, 277 (1978).
Allan, D. & Thomas, P. Biochem. J. 198, 433 (1981).
Allan, D. & Thomas, P. Biochem. J. 198, 441 (1981).
Kuettner, J. F. et al. Am. J. Path. 88, 81 (1977).
Koppel, D. E., Sheetz, M. P. & Schindler, M. Proc. natn. Acad. Sci. U.S.A. 78, 3576 (1981).
Schindler, M., Koppel, D. & Sheetz, M. P. Proc. natn. Acad. Sci. U.S.A. 77, 1457 (1980).
Koppel, D. E. Biophys. J. 28, 281 (1979).
Koppel, D. E., Sheetz, M. P. & Schindler, M. Biophys. J. 30, 187 (1980).
Koppel, D. E. & Sheetz, M. P. Nature 293, 159 (1981).
Schacht, J. J. Lipid Res. 19, 1063 (1978).
Sheetz, M. P. & Casaly, J. J. biol. Chem. 255, 9955 (1980).
Sheetz, M. P. & Casaly, J. Scand. J. clin. Lab. Invest. 41, Suppl. 156, 113 (1981).
Wolfe, L. C., Lux, S. E. & Ohanian, V. J. supramolec Struct. Suppl. 5, 123 (1981).
Shapiro, D. L. & Marchesi, V. T. J. biol. Chem. 252, 508 (1977).
Shukla, S. D., Coleman, R., Finean, J. B. & Michell, R. H. Biochem. J. 179, 441 (1979).
Ryu, E. K. & MacCoss, M. J. Lipid Res. 20, 561 (1979).
Gonzalez-Sastre, F. & Folch-Pi, J. J. Lipid Res. 9, 532 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sheetz, M., Febbroriello, P. & Koppel, D. Triphosphoinositide increases glycoprotein lateral mobility in erythrocyte membranes. Nature 296, 91–93 (1982). https://doi.org/10.1038/296091a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/296091a0
This article is cited by
-
Effect of a phorbol ester on basic surface properties of trichomonads
Cell Biophysics (1992)
-
The polyphosphoinositides, phosphatidylinositol monophosphate and phosphatidylinositol bisphosphate, are present in nuclei isolated from carrot protoplast
Protoplasma (1989)
-
Ethanol-induced alterations in human erythrocyte shape and surface properties: Modulatory role of prostaglandin E1
The Journal of Membrane Biology (1987)
-
Polyphosphoinositides and the shape of mammalian erythrocytes
Lipids (1985)
-
Fertilization increases the polyphosphoinositide content of sea urchin eggs
Nature (1984)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
