Abstract
The kinetics of the thrombin-catalysed release of fibrino-peptides A and B from human fibrinogen have been investigated and a mechanism correlating the release of fibrinopeptides to fibrin formation is presented. The sequential release of fibrinopeptides results in sequential activation of two sets of polymerisation sites.
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Blombäck, B., Hessel, B., Hogg, D. et al. A two-step fibrinogen–fibrin transition in blood coagulation. Nature 275, 501–505 (1978). https://doi.org/10.1038/275501a0
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DOI: https://doi.org/10.1038/275501a0
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