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Antileishmanial activity of antimonials entrapped in liposomes

Nature volume 272, pages 55–56 (1978)Cite this article

Abstract

THE use of liposomes in chemotherapy as a method of ensuring that drugs reach the diseased or defective tissues suffers from the drawback that, on intravenous injection, the bulk of the material is rapidly cleared by the phagocytic cells of the liver1, and does not reach the desired target. We report here a system in which advantage is taken of this behaviour to treat visceral leishmaniasis in mice, in which the amastigote parasites reside unharmed in vacuoles inside the Küpffer cells of the liver2.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Liverpool, PO Box 147, Liverpool, UK

    R. R. C. NEW

  2. Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK

    M. L. CHANCE, S. C. THOMAS & W. PETERS

Authors
  1. R. R. C. NEW
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  2. M. L. CHANCE
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  3. S. C. THOMAS
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  4. W. PETERS
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NEW, R., CHANCE, M., THOMAS, S. et al. Antileishmanial activity of antimonials entrapped in liposomes. Nature 272, 55–56 (1978). https://doi.org/10.1038/272055a0

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