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Coupling PPD to tumour cells enhances their antigenicity in BCG-primed mice

Nature volume 271, pages 463–464 (1978)Cite this article

Abstract

STUDIES of cell cooperation and of the carrier effect in the induction of antibody formation and in delayed hypersensitivity1 can predict, and have indeed shown2–4, that combining an antigenic determinant which evokes a powerful T cell response with a weak antigen should greatly enhance the immunogenicity of the latter by providing ‘antigenic help’.

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References

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Authors and Affiliations

  1. MRC Group on Mechanisms in Tumour Immunity and Tumour Biology Group, Tumour Biology Group, The Laboratory of Molecular Biology, Hills Road, Cambridge, UK

    P. J. LACHMANN & K. SIKORA

Authors
  1. P. J. LACHMANN
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  2. K. SIKORA
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LACHMANN, P., SIKORA, K. Coupling PPD to tumour cells enhances their antigenicity in BCG-primed mice. Nature 271, 463–464 (1978). https://doi.org/10.1038/271463a0

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