Abstract
OVER 20 years ago, Stotz et al.1 reported that administration of oestrogen to rats effected an increase in the peroxidase (EC 1. 11. 1. 7) activity of the uterus. Subsequently, this stimulation of uterine peroxidase activity was attributed to an influx of eosinophils into the tissue2. More recent evidence, both biochemical3–5 and histochemical6–7, clearly indicates a uterine origin for the enzyme. On the basis of histochemical peroxidase assays, we proposed that peroxidase may be a useful marker protein response elicited by oestrogen in those rat tissues, like uterus8, vagina8 and mammary tumour9, whose growth is regulated by oestrogen. Recent data10 on the dose and steroid dependence of rat uterine peroxidase induction also supports this proposition. To be a meaningful marker for the effect of oestrogen on growth responsive tissues, the peroxidase induction should be demonstrable in animals other than the rat and should show a reasonable tissue specificity. This communication reports on the generality and specificity of oestrogen regulation of peroxidase activity.
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LYTTLE, C., DESOMBRE, E. Generality of oestrogen stimulation of peroxidase activity in growth responsive tissues. Nature 268, 337–339 (1977). https://doi.org/10.1038/268337a0
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DOI: https://doi.org/10.1038/268337a0
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