Abstract
THE mammalian epidermis contains a system of dendritic cells, eponymously referred to as Langerhans cells, whose functions are obscure. It is, however, accepted that Langerhans cells are of mesenchymal origin and since they are known also to occur in the dermis, lymph nodes, thymus, and other organs, the concept of Langerhans cells has widened to encompass a cellular system populating the connective tissues and certain stratified squamous epithelia of mammals1. Among the many hypotheses about their biological significance they have been considered to represent immunocompetent cells or cells which might capture antigenic materials2, but there is insufficient evidence for this. Lymphocytes have been observed to be closely associated with Langerhans cells in delayed type hypersensitivity reactions to dinitrochloro-benzene in guinea pigs3; and when guinea pigs passively sensitised with lymphocytes from ferritin-hypersensitive donors, were challenged with ferritin, ferritin-containing Langerhans cells were observed in the draining lymph nodes of the challenged animals4. Metals and certain amines have an affinity for Langerhans cells in vitro5, but since they can phagocytose ferritin and other substances without previous sensitisation1, doubt remains whether they are immunologically engaged in the uptake and transport of potentially antigenic material. If Langerhans cells are indeed involved in immunological reactions, they should bear some of the surface markers characteristics of cells with known immunological functions, and we have now shown that they carry receptors for Fc and C3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Wolff, K. Curr. Probl. Derm, 4, 79–145 (1972).
Prunieras, M. J. Invest. Derm. 52, 1–17 (1969).
Silberberg, I., Baer, R. & Rosenthal, S. A. Acta dermatovener. 54, 321–331 (1974).
Silberberg-Sinakin, I., Thorbecke, G. J., Baer, R., Rosenthal, S. A. & Berezowsky, V. Cell. Immun. 25, 137–151 (1976).
Shelley, W. B. & Juhlin, L. Nature 261, 46–47 (1976).
Kiistala, U. J. Invest. Derm. 50, 129–137 (1968).
Pichler, W. J. & Knapp, W. J. Immun. 118, 1010–1015 (1977).
Nisonoff, A., Wissler, F. C., Lipman, L. N. & Woernley, D. L. Archs Biochem. Biophys. 89, 230 (1960).
Lay, W. H. & Nussenzweig, V. J. exp. Med. 128, 991–1007 (1968).
Wachstein, M. & Meisel, E. Am. J. clin. Path. 72, 13–23 (1963).
Parish, C. R. Transplant. Rev. 25, 98–120 (1975).
Huber, H., Polley, M. J., Linscott, W. D., Fudenberg, H. H. & Mueller-Eber-hard, H. J. Science 162, 1281–1283 (1968).
Hopf, U., Meyerzum Buschenfelde, K. H. & Dierich, M. P. J. Immun. 117, 639–645 (1976).
Wolff, K. & Schreiner, E. J. Invest. Derm. 54, 37–47 (1970).
Basset, F. & Nezelof, C. Soc. Med. Hop., Paris 117, 413–426 (1966).
Waldron, J. A., Horn, R. G. & Rosenthal, A. S. J. Immun. 111, 58–64 (1973).
Rosenthal, A. S., Lipsky, P. E. & Shevach, E. M. Fedn Proc. 34, 1743–1748 (1975).
Feldman, M. J. exp. Med. 136, 737–760 (1972).
Gelfand, E. W., Resch, K. & Prester, M. Eur. J. Immun. 2, 419–424 (1972).
Mantovani, B., Rabinovitch, M. & Nussenzweig, V. J. exp. Med. 135, 780–792 (1972).
Liew, F. Y. & Parish, C. R. Cell. Immun. 5, 520–535 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
STINGL, G., WOLFF-SCHREINER, E., PICHLER, W. et al. Epidermal Langerhans cells bear Fc and C3 receptors. Nature 268, 245–246 (1977). https://doi.org/10.1038/268245a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/268245a0
This article is cited by
-
Ontogeny and function of murine epidermal Langerhans cells
Nature Immunology (2017)
-
Ontogeny and homeostasis of Langerhans cells
Immunology & Cell Biology (2010)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.