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Relationship between receptor and mammary tumour virus production after stimulation by glucocorticoid

Nature volume 262, pages 107–112 (1976)Cite this article

Abstract

A short exposure of primary cultures of mouse mammary tumour cells to glucocorticoids results in at least a threefold stimulation of mammary tumour virus (MTV) production. Specific interaction of glucocorticoids with the cytoplasmic and nuclear receptors can also be demonstrated. The biological potency of various steroids to stimulate MTV is related directly to the retention of the steroid–receptor complex in the nuclei. Progesterone has a high affinity for the cytoplasmic receptor, is not retained by the nuclei and does not stimulate or block the basal level of MTV production. It is, however, quite effective in abolishing the glucocorticoid-mediated stimulation of MTV and thus behaves as an antagonist of glucocorticoid.

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Author information

Author notes

  1. G. Shyamala

    Present address: Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste-Catherine Road, Montreal, Quebec, Canada, H3T 1E2

  2. C. Dickson

    Present address: Imperial Cancer Research Fund, Lincoln's Inn Fields, London, WC2A 3PX, UK

Authors and Affiliations

  1. Department of Zoology and Cancer Research Laboratory, University of California, Berkeley, California, 94720

    G. Shyamala & C. Dickson

Authors
  1. G. Shyamala
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  2. C. Dickson
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Shyamala, G., Dickson, C. Relationship between receptor and mammary tumour virus production after stimulation by glucocorticoid. Nature 262, 107–112 (1976). https://doi.org/10.1038/262107a0

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