Abstract
CARSWELL et al.1 described a tumour necrosis factor (TNF) in the sera of mice sensitised with BCG and injected with endotoxin. After intravenous injection of this serum into mice bearing a 7-d-old transplant of a tumour originally induced by methylcholanthrene, necrosis of the tumour began within 12–24 h. A similar response was found in mice bearing various other tumours. We have now found that both whole TNF serum and TNF partially purified from mouse serum2 inhibit the growth of a human melanoma cell line.
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References
Carswell, E. A., et al., Proc. natn. Acad. Sci. U.S.A., 72, 3666–3670 (1975).
Green, S., et al., Proc. natn. Acad. Sci. U.S.A. (in the press).
Everson, T. C., Cole, W. H., Ann. Surg., 144, 366–383 (1956).
Nathanson, L., Cancer Chemother. Rep., 56, 659–665 (1972).
Biedler, J. L., Helson, L., and Spengler, B. A., Cancer Res., 33, 2643–2652 (1973).
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HELSON, L., GREEN, S., CARSWELL, E. et al. Effect of tumour necrosis factor on cultured human melanoma cells. Nature 258, 731–732 (1975). https://doi.org/10.1038/258731a0
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DOI: https://doi.org/10.1038/258731a0
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