Abstract
SEVERAL physical and chemical agents can induce susceptible mammalian cell populations to accumulate in the G2 phase of the cell cycle1–8. The question arises whether cells treated with different agents all accumulate at a single ‘restriction’ stage within G2 or, alternatively, stop at a variety of stages.
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References
Sinclair, W., Radiat. Res., 33, 620–643 (1968).
Walters, R. A., and Tobey, R. A., Biophys. J., 10, 556–562 (1970).
Leeper, D. B., Schneiderman, M. H., and Dewey, W. C., Radiat. Res., 53, 326–337 (1973).
Gerner, E. W., Meyn, R. E., and Humphrey, R. M., Radiat. Res., 60, 62–74 (1974).
Bhuyan, B. K., Cancer Res., 30, 2017–2023 (1970).
Shirakawa, S., and Frei, E., III, Cancer Res., 30, 2173–2179 (1970).
Barranco, S. C., and Humphrey, R. M., Cancer Res., 31, 191–195 (1971).
Tobey, R. A., and Crissman, H., Cancer Res. 35, 460–470 (1974).
Tobey, R. A., Petersen, D. F., Anderson, E. C., and Puck, T. T., Biophys. J., 6, 567–581 (1966).
Nagao, T., Kamimura, O., Takahara, I., and Hiraki, K., Japan J. clin. Hematol., 14, 925–930 (1973).
Sawada, H., Tatsumi, K., Sasada, M., Shirakawa, S., Nakamura, T., and Wakisada, G., Cancer Res., 34, 3341–3346 (1974).
Tobey, R. A., Oka, M. S., and Crissman, H. A., Eur. J. Cancer (in the press).
Tobey, R. A., J. Cell Physiol., 79, 259–266 (1972).
Mitchison, J. M., The Biology of the Cell Cycle (Cambridge University Press, Cambridge, 1971).
Scudiero, D., and Strauss, B., J. molec. Biol., 83, 17–34 (1974).
Ljungquist, A. A., and Lindahl, T., J. biol. Chem., 249, 1536–1540 (1974).
Thompson, L. H., and Baker, R. M., in Methods in Cell Biology, 6 (edit. by Prescott, D. M.), 209–281 (Academic, New York, 1973).
Basilico, C., and Meiss, H. K., in Methods in Cell Biology 8 (edit. by Prescott, D. M.), 1–22 (Academic, New York, 1974).
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TOBEY, R. Different drugs arrest cells at a number of distinct stages in G2. Nature 254, 245–247 (1975). https://doi.org/10.1038/254245a0
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DOI: https://doi.org/10.1038/254245a0
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