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Crystallisation of a modified fibrinogen

Abstract

MOST fibrous proteins do not crystallise. An artful way to promote protein crystallisation is to modify the structure by proteolytic attack. For example, papain cleavage of γ-globulin yields the homogeneous Fc fragment which readily crystallises1. Following a similar approach, we have crystallised fibrinogen.

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COHEN, C., TOONEY, N. Crystallisation of a modified fibrinogen. Nature 251, 659–660 (1974). https://doi.org/10.1038/251659a0

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