Abstract
A new theory is proposed to explain the synthesis of the 5′ ends of linear DNA molecules. It suggests that chromosome ends consist of palindromic base sequences. These can form self-complementary hairpin loops, which can be converted by DNA ligase, a specific endonuclease, and DNA polymerase, into completely replicated ends.
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Cavalier-Smith, T. Palindromic base sequences and replication of eukaryote chromosome ends. Nature 250, 467–470 (1974). https://doi.org/10.1038/250467a0
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DOI: https://doi.org/10.1038/250467a0
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