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Stimulation of tumour cell dissemination by raised temperature (42°C) in rats with transplanted Yoshida tumours

Nature volume 248, pages 354–358 (1974)Cite this article

Abstract

HYPERTHERMIA, that is, temperatures ≥40° C, may have a selective destructive effect on some types of cancer cells1,2, and sporadic attempts have been made to treat human cancer by raised temperatures1–3. Rossi-Fanelli and colleagues have demonstrated a selective and irreversible inhibition of metabolism in a variety of tumour cells at 42° C, whereas normal cells were unaffected1,4,5. These workers obtained histological regression of malignant limb tumours in patients treated by regional per fusion with pre warmed blood1. More effective and controlled methods for inducing hyperthermia6, and reports that the action of cytotoxic drugs can be potentiated by hyperthermia7,8, have further stimulated interest in this approach to the treatment of human malignjant tumours.

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Authors and Affiliations

  1. Cancer Research Unit, Department of Clinical Biochemistry, and Department of Pathology, Royal Victoria Infirmary, Newcastle-upon-Tyne

    J. A. DICKSON & H. A. ELLIS

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  1. J. A. DICKSON
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  2. H. A. ELLIS
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DICKSON, J., ELLIS, H. Stimulation of tumour cell dissemination by raised temperature (42°C) in rats with transplanted Yoshida tumours. Nature 248, 354–358 (1974). https://doi.org/10.1038/248354a0

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