Abstract
THE mechanism whereby thymus-derived (T) and bone marrow or bursa-derived (B) lymphocytes cooperate in the induction of an antibody response is of great importance in immunology. It has been suggested that T cells concentrate antigen by their surface receptors to present a multideterminant antigen array directly to B cells1,2; or that T cells secrete a special class of cooperating antibody (IgX) for this purpose, which could specifically present antigen at the surface of a third cell, the macrophage3,4; or that the product of recognition of antigen by T cells has some non-specific mitogenic or stimulatory effect on B cells5,6. Recent work with in vitro systems has indicated that various factors produced by T cells, either after contact with a specific antigen or following stimulation by allogeneic cells, can replace the requirement for T cells in antibody formation7–14.
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TAUSSIG, M. T cell factor which can replace T cells in vivo. Nature 248, 234–236 (1974). https://doi.org/10.1038/248234a0
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DOI: https://doi.org/10.1038/248234a0
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