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General Model for the Chromosomes of Higher Organisms

Abstract

The model suggests that chromosomal DNA falls into two classes: globular DNA (containing unpaired regions for control) and a much smaller fraction consisting of fibrous DNA which alone codes for proteins.

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References

  1. Britten, R. J., and Davidson, E. H., Science, 165, 349 (1969).

    Article  ADS  CAS  Google Scholar 

  2. Prescott, D. M., in Advances in Cell Biology, 1 (edit. by Prescott, D. M., Goldstein, L., and McConkey, E.), 57 (North Holland, Amsterdam, 1970).

    Google Scholar 

  3. Laird, C. D., Chromosoma, 32, 378 (1971).

    Article  CAS  Google Scholar 

  4. Beermann, W., in Cell Differentiation and Morphogenesis, 24 (North-Holland, Amsterdam, 1966).

    Google Scholar 

  5. King, D. W., and Barnhisel, M. L., J. Cell Biol., 33, 265 (1967).

    Article  CAS  Google Scholar 

  6. Vogel, F., Nature, 201, 847 (1964).

    Article  ADS  CAS  Google Scholar 

  7. Lindsley, D. L., and Grell, E. H., Genetic Variation in Drosophila melanogaster (Carnegie Inst. Washington, Publ. 627, 1968).

    Google Scholar 

  8. MacInnes, J. W., and Uretz, R. B., Science, 151, 689 (1966).

    Article  ADS  CAS  Google Scholar 

  9. Gierer, A., Nature, 212, 1480 (1966).

    Article  ADS  CAS  Google Scholar 

  10. Histones and Nucleohistones (edit. by Philips, D. M. P.) (Plenum, New York and London, 1971).

  11. DuPraw, E. J., DNA and Chromosomes (Holt, Rinehart and Winston, 1970).

    Google Scholar 

  12. Pardon, J. F., Wilkins, M. H. F., and Richards, B. M., Nature, 215, 509 (1967).

    Article  ADS  Google Scholar 

  13. Southern, E. M., Nature, 227, 794 (1970).

    Article  ADS  CAS  Google Scholar 

  14. Jones, K. W., Nature, 225, 912 (1970).

    Article  ADS  CAS  Google Scholar 

  15. Pardue, M. L., and Gall, H. G., Science, 168, 1356 (1970).

    Article  ADS  CAS  Google Scholar 

  16. Muller, H. J., in Heritage from Mendel (edit. by Brink, R. A.), 419 (University of Wisconsin Press, Madison, 1967).

    Google Scholar 

  17. Shannon, M. P., Kaufman, T. C., and Judd, B. H., Genetics, 64, s58 (1970).

    Google Scholar 

  18. Baker, W. K., Adv. Genetics, 14, 133 (1968).

    Article  CAS  Google Scholar 

  19. Sutton, W. D., and McCullum, M., Nature, 232, 83 (1971).

    Article  CAS  Google Scholar 

  20. Thomas, jun., C. A., Hamkalo, B. A., Misra, D. N., and Lee, C. S., J. Mol. Biol., 51, 621 (1970).

    Article  Google Scholar 

  21. Scherrer, K., Spohr, G., Granboulan, N., Morel, C., Grosclaude, J., and Chezzi, C., Cold Spring Harbor Symp. Quant. Biol., 35, 539 (1970) and other papers in the same volume.

    Article  CAS  Google Scholar 

  22. Georgiev, G. P., J. Theoret. Biol., 25, 473 (1969).

    Article  CAS  Google Scholar 

  23. Ryskov, A. P., and Georgiev, G. P., Febs Letters, 8, 186 (1970).

    Article  Google Scholar 

  24. Coutelle, C., Ryskov, A. P., and Georgiev, G. P., Febs Letters, 12, 21 (1970).

    Article  CAS  Google Scholar 

  25. Luzzati, V., and Nicolaieff, A., J. Mol. Biol., 7, 142 (1963).

    Article  CAS  Google Scholar 

  26. Nature New Biology, 231, 68 (1971).

Download references

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CRICK, F. General Model for the Chromosomes of Higher Organisms. Nature 234, 25–27 (1971). https://doi.org/10.1038/234025a0

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