Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Role of Methionine in the Initiation of Haemoglobin Synthesis

Abstract

The α and β chains of rabbit globin are initiated by the incorporation of a methionine residue in the N-terminal position. This methionine is removed during the early stages of chain growth.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Marcker, K. A., and Smith, A. E., Bull. Soc. Chim. Biol., 51, 1453 (1969).

    CAS  Google Scholar 

  2. Wilson, D. B., and Dintzis, H., Cold Spring Harbor Symp. Quant. Biol., 34, 313 (1969).

    Article  CAS  Google Scholar 

  3. Rich, A., Eikenberry, E. F., and Malkin, L. I., Cold Spring Harbor Symp. Quant. Biol., 31, 303 (1966).

    Article  CAS  Google Scholar 

  4. Arnstein, H. R. V., and Rahamimoff, H., Nature, 219, 942 (1968).

    Article  ADS  CAS  Google Scholar 

  5. Rahamimoff, H., and Arnstein, H. R. V., Biochem. J., 115, 113 (1969).

    Article  CAS  Google Scholar 

  6. Gonano, F., and Baglioni, C., Europ. J. Biochem., 11, 7 (1969).

    Article  CAS  Google Scholar 

  7. Mosteller, R. D., Culp, W. J., and Hardesty, B., J. Biol. Chem., 243, 6343 (1968).

    CAS  Google Scholar 

  8. Conconi, F. M., Bank, A., and Marks, P. A., J. Mol. Biol., 19, 525 (1966).

    Article  CAS  Google Scholar 

  9. Lin, S-Y., Mosteller, R. D., and Hardesty, B., J. Mol. Biol., 21, 51 (1966).

    Article  CAS  Google Scholar 

  10. Ravel, J., Mosteller, R. D., and Hardesty, B., Proc. US Nat. Acad. Sci., 56, 701 (1966).

    Article  ADS  CAS  Google Scholar 

  11. Hunt, T., Hunter, A. R., and Munro, A. J., J. Mol. Biol., 36, 31 (1968).

    Article  CAS  Google Scholar 

  12. Vazquez, D., Battaner, E., Neth, R., Heller, G., and Monro, R. E., Cold Spring Harbor Symp. Quant. Biol., 34, 369 (1969).

    Article  CAS  Google Scholar 

  13. Leder, P., and Bursztyn, H., Biochem. Biophys. Res. Commun., 25, 233 (1966).

    Article  CAS  Google Scholar 

  14. Braunitzer, G., Best, J. S., Flamm, U., and Schrank, B., Z. Physiol. Chem, 347, 207 (1966); von Ehrenstein, G., Cold Spring Harbor Symp. Quant. Biol., 31, 705 (1966).

    Article  CAS  Google Scholar 

  15. Gray, W. J., in Methods in Enzymology (edit. by Colowick, S. P., and Kaplan, N. O.), 11, 469 (Academic Press, New York and London, 1967).

    Google Scholar 

  16. Leggett Bailey, J., in Techniques in Protein Chemistry, second ed., 193 (Elsevier, Amsterdam, 1967).

    Google Scholar 

  17. Gross, E., and Witkop, B., J. Biol. Chem., 237, 1856 (1962).

    CAS  Google Scholar 

  18. Lodish, H. F., Nature, 220, 345 (1968).

    Article  ADS  CAS  Google Scholar 

  19. Waley, S. G., and Watson, J., Biochem. J., 55, 328 (1953).

    Article  CAS  Google Scholar 

  20. Brown, J. C., and Smith, A. E., Nature, 226, 610 (1970).

    Article  ADS  CAS  Google Scholar 

  21. Malkin, L. I., and Rich, A., J. Mol. Biol., 26, 329 (1967).

    Article  CAS  Google Scholar 

  22. Smith, A. E., and Marcker, K. A., Nature, 226, 607 (1970).

    Article  ADS  CAS  Google Scholar 

  23. Wilson, D. B., and Dintzis, H., Proc. US Nat. Acad. Sci. (in the press).

  24. Housman, D., Jacobs-Lorena, M., RajBhandary, U. L., and Lodish, H. F., Nature (in the press).

  25. Sarimo, S. S., and Pine, M. J., J. Bact., 98, 368 (1969).

    CAS  PubMed  Google Scholar 

  26. Atlas of Protein Sequence and Structure (edit. by Dayhoff, M. O., and Eck, R. V.) (National Biomedical Research Foundation, 1969).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

JACKSON, R., HUNTER, T. Role of Methionine in the Initiation of Haemoglobin Synthesis. Nature 227, 672–676 (1970). https://doi.org/10.1038/227672a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/227672a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing