Abstract
THE existence of an electrical potential difference at the mitochondrial membrane is one of the postulates of Mitchell's chemiosmotic theory of oxidative phosphorylation1,2. A shunting of the mitochondrial membrane leads to the uncoupling of oxidative phosphorylation. It has been demonstrated that uncoupling agents increase the proton permeability of phospholipid micelle membranes3 and artificial bimolecular membranes4–7. Mitchell and Moyle8 showed that uncouplers can operate as proton carriers in mitochondrial membranes.
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References
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LIBERMAN, E., TOPALY, V., TSOFINA, L. et al. Mechanism of Coupling of Oxidative Phosphorylation and the Membrane Potential of Mitochondria. Nature 222, 1076–1078 (1969). https://doi.org/10.1038/2221076a0
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DOI: https://doi.org/10.1038/2221076a0
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