Abstract
Moore and Underwood1 showed that subcutaneous injection of noradrenaline in the newborn kitten produced a marked increase in metabolic rate, whereas adrenaline in the same dose was relatively inactive. A similar stimulation of metabolism in the newborn animal after the injection of noradrenaline was observed in the rabbit and rat2 and in the human infant3. Subsequent work on the newborn rabbit showed the probable relation between the effect of noradrenaline and the activity of brown fat. Local heat production in brown fat is increased by the infusion of noradrenaline4. When the brown fat is excised, the rise in oxygen consumption during infusion is greatly reduced5. These observations suggested that the effect of noradrenaline should be investigated in the newborn pig, which seems to have no brown fat, and only about 1 per cent total fat in the body at birth6. The amount increases rapidly to reach about 10 per cent at 1 week of age7.
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References
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LEBLANC, J., MOUNT, L. Effects of Noradrenaline and Adrenaline on Oxygen Consumption Rate and Arterial Blood Pressure in the Newborn Pig. Nature 217, 77–78 (1968). https://doi.org/10.1038/217077a0
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DOI: https://doi.org/10.1038/217077a0
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