Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Circular Dimer and Catenate Forms of Mitochondrial DNA in Human Leukaemic Leucocytes

Abstract

Oligomer forms of circular mitochondrial DNA have been identified in mitochondrial extracts of human leukaemic leucocytes. The oligomers occur as circular dimers with a contour length of 10µ and catenanes made up of interlocked 5µ monomers.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Van Bruggen, E. F. J., Borst, P., Ruttenberg, G. J. C. M., Gruber, M., and Kroon, A. M., Biochim. Biophys. Acta, 119, 437 (1966).

    Article  CAS  Google Scholar 

  2. Kroon, A. M., Borst, P., Van Bruggen, E. F. J., and Ruttenberg, G. J. C. M., Proc. US Nat Acad. Sci., 56, 1836 (1966).

    Article  ADS  CAS  Google Scholar 

  3. Pikó, L., Tyler, A., and Vinograd, J., Biol. Bull., 132, 68 (1967).

    Article  Google Scholar 

  4. Vinograd, J., Lebowitz, J., Radloff, R., Watson, R., and Laipis, R., Proc. US Nat. Acad. Sci., 53, 1104 (1965).

    Article  ADS  CAS  Google Scholar 

  5. Vinograd, J., and Lebowitz, J., J. Gen. Physiol., 49, 103 (1966).

    Article  CAS  Google Scholar 

  6. Bauer, W., and Vinograd, J., J. Mol. Biol. (in the press).

  7. Radloff, R., Bauer, W., and Vinograd, J., Proc. US Nat. Acad. Sci., 57, 1514 (1967).

    Article  ADS  CAS  Google Scholar 

  8. Lehninger, A. L., The Mitochondrion, 31 (W. A. Benjamin, Inc., New York, 1964).

    Google Scholar 

  9. Borst, P., Kroon, A. M., and Ruttenberg, G. J. C. M., Symp. on Structure and Function of Genetic Elements, Warsaw, 1966, 95 (Academic Press and P.W.N., London and Warsaw, 1967).

    Google Scholar 

  10. Kleinschmidt, A. K., and Zahn, R. K., Z. Naturforsch., 14b, 770 (1959).

    Article  Google Scholar 

  11. Hirt, B., J. Mol. Biol., 26, 365 (1967).

    Article  CAS  Google Scholar 

  12. Vinograd, J., Bruner, R., Kent, R., and Weigle, J., Proc. US Nat. Acad. Sci., 49, 902 (1963).

    Article  ADS  CAS  Google Scholar 

  13. Bruner, R., and Vinograd, J., Biochim. Biophys. Acta, 108, 18 (1965).

    Article  CAS  Google Scholar 

  14. Burton, A., and Sinsheimer, R. L., J. Mol. Biol., 14, 3276 (1965).

    Article  Google Scholar 

  15. Ray, D. S., Preuss, A., and Hofschneider, P. H., J. Mol. Biol., 21, 485 (1966).

    Article  CAS  Google Scholar 

  16. Crawford, L. V., J. Mol. Biol., 13, 362 (1965).

    Article  CAS  Google Scholar 

  17. Wang, J. C., Baumgarten, D., and Olivera, B. M., Proc. US Nat. Acad. Sci. (in the press).

  18. Studier, F. W., J. Mol. Biol., 11, 373 (1965).

    Article  CAS  Google Scholar 

  19. Vinograd, J., and Hearst, J. E., in Fortschritte der Chemie Organischer Naturstoffe (edit. by Zechmeister, L.), 20, 372 (Springer-Verlag, Vienna, 1962).

    Google Scholar 

  20. Schildkraut, C. L., Marmur, J., and Doty, P., J. Mol. Biol., 4, 430 (1962).

    Article  CAS  Google Scholar 

  21. Wintrobe M. M., Clinical Haematology, fifth ed., 249 (Lea and Febiger, Philadelphia, 1961).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

CLAYTON, D., VINOGRAD, J. Circular Dimer and Catenate Forms of Mitochondrial DNA in Human Leukaemic Leucocytes. Nature 216, 652–657 (1967). https://doi.org/10.1038/216652a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/216652a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing