Abstract
ATTEMPTS to measure the rate of exchange of labelled sodium in isolated mammalian muscle have been beset with numerous difficulties. The fibre sodium may show a marked increase1, the fall in radioactivity of the muscle during a washout may not be linear when plotted on semi-logarithmic paper2, and the thickness of the tissue may slow the exchange. It is known, however, that muscles can be maintained for some hours with values of sodium and potassium which are very similar to those found in vivo if insulin or certain plasma proteins are present3,4, and this finding led to attempts to detect the effect of insulin on sodium movements. A method has been used which can give consistent results when applied to diaphragm muscle and in which the effects due to the rib and attached tissue are avoided.
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References
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CREESE, R. Sodium Exchange in Rat Muscle. Nature 201, 505–506 (1964). https://doi.org/10.1038/201505b0
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DOI: https://doi.org/10.1038/201505b0
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