Abstract
THE effect of ketone bodies on carbohydrate metabolism is still obscure, and several theories have been proposed to explain their action1–3. Nagler4 incubated surviving rat diaphragm in phosphate buffer medium containing glucose . (200 mgm. per cent), glucose and insulin (0.05 unit per 1.0 ml.), glucose, insulin and acetoacetate (50 mgm. per cent). No effect of acetoacetate on glycogen synthesis was observed. Parnes and Wertheimer5 reported that acetoacetate depressed glycogen synthesis in the rat diaphragm, thus differing from other metabolites.
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References
Nath, M. C., and Brahmachari, H. D., Nature, 154, 487 (1944): 157, 336 (1946).
Tidwell, H. C., and Axelrod, H. E., J. Biol. Chem., 172, 179 (1948).
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Parnes, I., and Wertheimer, E., Biochem. J., 46, 517 (1950).
Gemmill, C. L., Bull. Johns Hopkins Hosp., 66, 232 (1940); 68, 329 (1941).
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CHARI, A., WERTHEIMER, E. Effect of Acetoacetate on Glycogen Synthesis and Glucose Utilization in the Isolated Rat Diaphragm. Nature 171, 44–45 (1953). https://doi.org/10.1038/171044b0
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DOI: https://doi.org/10.1038/171044b0
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