Abstract
CRUDE preparations of deoxypentose nucleic acids are almost invariably contaminated with pentose nucleic acids. This admixture renders many studies of the chemical and biological specificity of nucleic acids difficult. A preliminary separation must be carried out before the exact determination of the constituent purines and pyrimidines becomes possible1. Only in a few cases (sperm, thymus and, possibly, spleen) will suitable washing of the biological material, prior to its extraction, sufficiently depress the extent of contamination of the nucleic acid specimens2–4.
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ZAMENHOF, S., CHARGAFF, E. Separation of Deoxypentose and Pentose Nucleic Acids. Nature 168, 604–605 (1951). https://doi.org/10.1038/168604a0
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DOI: https://doi.org/10.1038/168604a0
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