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Characterization of Lippia sidoides oil extract-b-cyclodextrin complexes using combined thermoanalytical techniques

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Abstract

Thermoanalytical techniques, being rapid and un-expensive have been used for the investigation of the cyclodextrin inclusion complexes for three decades. The conventional thermoanalytical techniques (TG and DTA/DSC) follow the thermal properties of the uncomplexed compounds. Consequently, the inclusion complex formation as well as the liberation of the entrapped guest cannot be followed. Monitoring the products of the thermal fragmentation of parent cyclodextrin and the included molecule(s), applying TG-MS combined technique provides evidence concerning the inclusion complex formation, and besides, gives selective signal to follow the decomposition of the cyclodextrin inclusion complexes. b-cyclodextrin inclusion complexes of Thymol and Lippia sidoides Cham essential oil extract have been prepared and investigated using conventional and combined (TG-MS) thermoanalytical techniques. The evolved gas analysis proved the inclusion complex formation between the host and guests. By the evaluation of the experimental results the elaboration of the entrapped guests from the cyclodextrin cavity could be followed.

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Authors and Affiliations

  1. Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Centro de Cięncias de Saúde, Av. Gal. Cordeiro de Farias s/n - Petrópolis, 59010-180, Natal, RN, Brazil

    L. P. Fernandes & T. F. Moura

  2. Institute of General and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellért tér 4, H-1111, Budapest, Hungary

    Zs. Éhen & J. Sztatisz

  3. Hungarian Academy of Sciences, Budapest University of Technology and Economics, Research Group of Technical Analytical Chemistry, Szt. Gellért tér 4, H-1111, Budapest, Hungary

    Cs. Novák

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  1. L. P. Fernandes
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  2. Zs. Éhen
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  3. T. F. Moura
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  4. Cs. Novák
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  5. J. Sztatisz
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Fernandes, L.P., Éhen, Z., Moura, T.F. et al. Characterization of Lippia sidoides oil extract-b-cyclodextrin complexes using combined thermoanalytical techniques. Journal of Thermal Analysis and Calorimetry 78, 557–573 (2004). https://doi.org/10.1023/B:JTAN.0000046119.33278.9f

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