Abstract
A preparative method for the synthesis of 7-carboxy-2-R-isoindol-1-ones was developed on the basis of the [4+2] cycloaddition of secondary furfurylamines to maleic anhydride.
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REFERENCES
D. T. Minh and J. E. Johnson, J. Org. Chem., 42, 4217(1977).
J. D. White and M. E. Mann, Adv. Heterocycl. Chem., 10, 113 (1969).
R. Bonnett and S. A. North, Adv. Heterocycl. Chem., 29, 341 (1981).
R. Fryor, J. V. Early, and L. U. Sternbach, J. Org. Chem., 34, 649 (1969).
M. S. Bailey, B. J. Brisdon, D. W. Brown, and K. M. Stark, Tetrahedron Lett., 24, 3037 (1983).
D. D. Sternbach, D. H. Rossane, and K. D. Onan, Tetrahedron Lett., 26, 591 (1985).
M. E. Gung and J. Gervay, Tetrahedron Lett., 29, 2429 (1988).
S. C. Hirst and A. D. Hamilton, J. Am. Chem. Soc., 113, 382 (1991).
M. Suzuki, T. Okada, T. Taguchi, Y. Hanzawa, and Y. Iitaka, J. Fluorine Chemistry, 57, 239 (1992).
D. Prajapati, D. R. Borthakur, and J. S. Sandhu, J. Chem. Soc. Perkin Trans. I, 1197 (1993).
K. H. Doetz, D. Boettcher, and M. Jendro, Inorg. Chim. Acta, 222, 291 (1994).
J. B. F. N. Engberts, Pure Appl. Chem., 67, 823 (1995).
K. Paulvannan, Tetrahedron Lett., 40, 1851 (1999).
A. Pelter and B. Singaram, J. Chem. Soc. Perkin Trans. I, 7, 1383 (1983).
A. Pelter and B. Singaram, Tetrahedron Lett., 23, 245 (1982).
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Varlamov, A.V., Boltukhina, E.V., Zubkov, F.I. et al. Preparative Synthesis of 7-Carboxy-2-R-isoindol-1-ones. Chemistry of Heterocyclic Compounds 40, 22–28 (2004). https://doi.org/10.1023/B:COHC.0000023763.75894.63
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DOI: https://doi.org/10.1023/B:COHC.0000023763.75894.63