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Tuberculosis in renal transplant recipients: Rifampicin sparing treatment protocol

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Abstract

The reactivation of mycobacterium infection inrenal transplant recipients in developingcountries is a common therapeutic dilemma,especially in those patients receivingcyclosporin immunosuppression. The inclusion ofrifampicin in the antituberculosis protocolincreases the risk of precipitating acuteallograft rejection due to its interaction withcyclosporin and also increases the financialburden. We successfully treated 16 patients whodeveloped mycobacterial infection post renaltransplant with a rifampicin sparingantituberculosis drug regimen. Pyrexia ofunknown origin was the most common manifestationobserved and a therapeutic trial withantituberculosis drugs is justified. De novodiabetes mellitus appears to be an added riskfactor and increases the susceptibility tomycobacterial infection.

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Authors and Affiliations

  1. Department of Transplantation, Bombay Hospital Institute of Medical Sciences, Mumbai, India

    Tushar J. Vachharajani, Umesh G. Oza, Ajit G. Phadke & Ashok L. Kirpalani

  2. Department of Nephrology, Louisiana State University Health Sciences Center, Shreveport, LA, USA

    Tushar J. Vachharajani

Authors
  1. Tushar J. Vachharajani
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  2. Umesh G. Oza
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  3. Ajit G. Phadke
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  4. Ashok L. Kirpalani
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Correspondence to Tushar J. Vachharajani.

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Vachharajani, T.J., Oza, U.G., Phadke, A.G. et al. Tuberculosis in renal transplant recipients: Rifampicin sparing treatment protocol. Int Urol Nephrol 34, 551–553 (2002). https://doi.org/10.1023/A:1025693521582

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